student from 01.01.2019 to 01.01.2021
Yaroslavl, Yaroslavl, Russian Federation
student from 01.01.2017 to 01.01.2021
Yaroslavl, Yaroslavl, Russian Federation
employee
Yaroslavl, Yaroslavl, Russian Federation
employee
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Several new short N-acyldipeptides containing the N-terminal 4-(1-adamantyl)benzoyl moiety have been synthesized using the classical peptide synthesis method in a solution based on N,N-carbonyldiimidazole. 1H NMR spectroscopy monitored the stereochemical purity of the desired compounds. It has been found that in the presence of an asymmetric carbon atom, a mixture of two diastereomers of N-acyldipeptides is formed in a non-contiguous amino acid residue. It has been suggested that this is due to the formation of an optically inactive oxazole intermediate at an intermediate stage. The synthesized compounds are of interest as potential therapeutic agents with antiviral activity in combination with low toxicity.
N-acyl dipeptides, N,N-carbonyl diamidazole, 4 - (1 adamantyl) benzoic acid, antiviral activity, diastereomers
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