Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
This article deals with the study of the nitration of 4-chloro-3-nitrobenzoic acid. The substrate is highly deactivated for SEAr reactions and therefore strict conditions are required (anhydrous KNO3 in concentrated H2SO4 at 165 °C for 10 hours). We have developed methods for the transformation of 4-chloro-3,5-dinitrobenzoic acid and its ester into new polycyclic systems containing pyridine or piperidine fragments by quaternization and reduction reactions.
4-chloro-3-nitrobenzoic acid, N-(2,6-dinitroaryl)pyridinium salts, N-(2,6-dinitroaryl)piperidines, nitration, pyridine quaternisation
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