employee from 01.01.2025 to 01.01.2026
Saint Petersburg, Russian Federation
Yaroslavl, Russian Federation
Saint Petersburg, Russian Federation
Saint Petersburg, Russian Federation
Yaroslavl, Russian Federation
student
Yaroslavl, Russian Federation
Saint Petersburg, Russian Federation
A series of eight new 2'-aminoaryloxadiazol-5(4H)-ones has been synthesized via the reduction of the corresponding nitro derivatives with tin(II) chloride. The antibacterial and fluorescent properties of the derivatives have been studied. We obtain the compound with moderate antibacterial activity against a sensitive strain of the Gram-positive bacterium Staphylococcus aureus ATCC-25923 (3-amino-4-(3-(3,4-dichlorophenyl)-5-oxo-1,2,4-oxadiazol-4(5H)-yl)benzonitrile, MIC 64 µg/mL. It demonstrates weak fluorescent properties upon irradiation with light at λ = 355 nm.
oxadiazol-5(4H)-one, reduction, tin(II) chloride, antibacterial activity, fluorescence
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