сотрудник с 01.01.2025 по 01.01.2026
Санкт-Петербург, Россия
Ярославль, Россия
Санкт-Петербург, Россия
Санкт-Петербург, Россия
Ярославль, Россия
студент
Ярославль, Россия
Санкт-Петербург, Россия
A series of eight new 2'-aminoaryloxadiazol-5(4H)-ones has been synthesized via the reduction of the corresponding nitro derivatives with tin(II) chloride. The antibacterial and fluorescent properties of the derivatives have been studied. We obtain the compound with moderate antibacterial activity against a sensitive strain of the Gram-positive bacterium Staphylococcus aureus ATCC-25923 (3-amino-4-(3-(3,4-dichlorophenyl)-5-oxo-1,2,4-oxadiazol-4(5H)-yl)benzonitrile, MIC 64 µg/mL. It demonstrates weak fluorescent properties upon irradiation with light at λ = 355 nm.
oxadiazol-5(4H)-one, reduction, tin(II) chloride, antibacterial activity, fluorescence
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