From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 127831 10.52957/2782-1900-2026-7-2-86-92 Научные статьи Scientific articles Научные статьи Synthesis, fluorescent and antibacterial properties of N-(2'-aminoaryl)-substituted 1,2,4-oxadiazol-5(4H)-ones Synthesis, fluorescent and antibacterial properties of N-(2'-aminoaryl)-substituted 1,2,4-oxadiazol-5(4H)-ones Шетнев Антон Андреевич Shetnev Anton Andreevich a.shetnev@list.ru

кандидат химических наук;

candidate of chemical sciences;

 Константинова Анна Сергеевна Konstantinova Anna Sergeevna

аспирант химических наук;

graduate student of chemical sciences;

 Романычева Анна Александровна Romanycheva Anna Aleksandrovna

кандидат биологических наук;

candidate of sciences in biology;

 Байков Сергей Валентинович Baykov Sergey Valentinovich

кандидат химических наук;

candidate of chemical sciences;

 Силин Александр Маркович Silin Alexander Markovich Калашников Павел Николаевич Kalashnikov Pavel Nikolaevich Корсаков Михаил Константинович Korsakov Mikhail Konstantinovich

доктор химических наук;

doctor of chemical sciences;

 Санкт Петербургский государственный университет Санкт Петербург Россия Санкт Петербургский государственный университет Санкт Петербург Russian Federation Ярославский государственный педагогический университет им. К.Д. Ушинского Yaroslavl State Pedagogical University named after K.D. Ushinsky Санкт Петербургский государственный университет Россия Санкт Петербургский государственный университет Russian Federation Санкт-Петербургский государственный университет St. Petersburg State University 10 07 2026 10 07 2026 7 2 86 92 29 04 2026 08 06 2026 https://chemintech.ru/en/nauka/article/127831/view

A series of eight new 2'-aminoaryloxadiazol-5(4H)-ones has been synthesized via the reduction of the corresponding nitro derivatives with tin(II) chloride. The antibacterial and fluorescent properties of the derivatives have been studied. We obtain the compound with moderate antibacterial activity against a sensitive strain of the Gram-positive bacterium Staphylococcus aureus ATCC-25923 (3-amino-4-(3-(3,4-dichlorophenyl)-5-oxo-1,2,4-oxadiazol-4(5H)-yl)benzonitrile, MIC 64 µg/mL. It demonstrates weak fluorescent properties upon irradiation with light at λ = 355 nm.

A series of eight new 2'-aminoaryloxadiazol-5(4H)-ones has been synthesized via the reduction of the corresponding nitro derivatives with tin(II) chloride. The antibacterial and fluorescent properties of the derivatives have been studied. We obtain the compound with moderate antibacterial activity against a sensitive strain of the Gram-positive bacterium Staphylococcus aureus ATCC-25923 (3-amino-4-(3-(3,4-dichlorophenyl)-5-oxo-1,2,4-oxadiazol-4(5H)-yl)benzonitrile, MIC 64 µg/mL. It demonstrates weak fluorescent properties upon irradiation with light at λ = 355 nm.

 oxadiazol-5(4H)-one reduction tin(II) chloride antibacterial activity fluorescence The study was conducted with the support of St. Petersburg State University Grant No. 126022017742-6.

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