graduate student
Moscow, Moscow, Russian Federation
student
Yaroslavl, Yaroslavl, Russian Federation
student
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Moscow Institute of Physics and Technology (State University)
from 01.01.2024 until now
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Razrabotan sposob sinteza novyh predstaviteley klassa pervichnyh benzolsul'fonamidov, perspektivnyh agentov dlya lecheniya otkrytougol'noy glaukomy i neyrodegenerativnyh zabolevaniy. Byla razrabotana metodika O-alkilirovaniya 4 gidroksibenzolsul'fonamida alkiliruyuschimi agentami razlichnoy prirody, obespechivayuschaya myagkie usloviya i selektivnost' processa. Pokazana neobhodimost' aktivacii N-zameschennyh 2-hloracetamidov i 5-(hlormetil)-3-aril-1,2,4-oksadiazolov kataliticheskoy dobavkoy yodida kaliya v reakciyah O-alkilirovaniya fenolov. Primenimost' razrabotannoy metodiki prodemonstrirovana na 12 primerah sinteza O alkilproizvodnyh 4-gidroksibenzolsul'fonamida, poluchennyh s vyhodami ot 28 do 86%. Chistota i stroenie novyh soedineniy dokazany sovokupnost'yu metodov YaMR 1N, 13S i elementnogo analiza.
sul'fanilamid, oksadiazol, O-alkilirovanie, karboangidraza, monoaminooksidaza
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