employee from 01.01.2009 until now
Yaroslavl, Yaroslavl, Russian Federation
graduate student
Yaroslavl, Yaroslavl, Russian Federation
student
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Predstavleno issledovanie po napravlennomu sintezu ranee ne opisannyh v literature zameschennyh metil (E) stirilpirimidin-5-karboksilatov, poluchennyh vzaimodeystviem digidropirimidin-2(1N)-onov s zameschennymi aromaticheskimi al'degidami. Stroenie poluchennyh soedineniy podtverzhdeno metodami YaMR-spektroskopii i mass-spektrometrii.
metil (E)-stiril-pirimidin-5-karboksilaty, hloristoe zhelezo, acetonitril
1. Sarvaiya B. H., Vaja P. I., Paghdar N. A., Ghelani S. M. Medicinal perspective of a promising scaffold dihydropyrimidinones: A review. J. Heterocycl. Chem., 2024, 61(8), 1325-1348. DOI:https://doi.org/10.1002/jhet.4855 EDN: https://elibrary.ru/PBINEF
2. A Naikoo R., A Mir M., Bhat S., Tomar R., A Bhat R., A Malla M. Biological activities and synthetic approaches of dihydropyrimidinones and thiones-an updated review. Curr. Bioact. Compd., 2016, 12(4), 236 250. DOI:https://doi.org/10.2174/15734072126661605171500
3. Adigun R. A., Malan F. P., Balogun M. O., October N. Design, synthesis, and in silico-in vitro antimalarial evaluation of 1, 2, 3-triazole-linked dihydropyrimidinone quinoline hybrids. Struct. Chem., 2023, 34(6), 2065 2082. DOI:https://doi.org/10.1007/s11224-023-02142-y EDN: https://elibrary.ru/ZJZUXM
4. Kanwal M., Nadeem H., Malik S., Maqsood S. Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties. Heliyon, 2025, 11(1). DOI:https://doi.org/10.1016/j.heliyon.2024.e41152 EDN: https://elibrary.ru/MNXGYT
5. Bhat M. A., Naglah A. M., Bakheit A. H., Al-Omar M. A., Ansari S. A., Alkahtani H. M., Aleanizy F. S., Eltayb E. K., Alqahtani F. Y. Novel indole derivatives of dihydropyrimidinone: Synthesis, characterization, molecular docking and antimicrobial activity. J. Mol. Struct., 2023, 1291, 136091. DOI:https://doi.org/10.1016/j.molstruc.2023.136091 EDN: https://elibrary.ru/XRKUQV
6. de Azambuja G. O., Svetaz L., Gonçalves I. L., Corbelini P. F., von Poser G. L., Kawano D. F., Zacchino S., Eifler-Lima V. L. In vitro antifungal activity of dihydropyrimidinones/thiones against Candida albicans and Cryptococcus neoformans. Curr. Bioact. Compd., 2019, 15(6), 648-655. DOI:https://doi.org/10.2174/1573407214666180926115745 EDN: https://elibrary.ru/REFAEV
7. Siva Ranjani J., Selvinthanuja C., Sivakumar T. # 195 Synthesis, characterization and antifungal activity of azo coupled dihydropyrimidinones. J. Pharm. Chem., 2022, 8(Supplement).
8. Khasimbi S., Ali F., Manda K., Sharma A., Chauhan G., Wakode S. Dihydropyrimidinones scaffold as a promising nucleus for synthetic profile and various therapeutic targets: A Review. Curr. Org. Synth., 2021, 18(3), 270-293. DOI:https://doi.org/10.2174/1570179417666201207215710 EDN: https://elibrary.ru/IRVDSH
9. Adriaty D., Suwito H., Puspaningsih N. N. T., Permanasari A. A., Nastri A. M., Shimizu K. In Vitro Antiviral Activity and Molecular Docking Analysis of Dihydropyrimidinone, Chromene and Chalcone Derivatives Against SARS-CoV-2. Trends in Sciences, 2026, 23(2). DOI:https://doi.org/10.48048/tis.2026.11438 EDN: https://elibrary.ru/GKWEFV
10. Kim J., Ok T., Park C., So W., Jo M., Kim Y., Seo M., Lee D., Jo S., Ko Y., Choi I., Park Y., Yoon J., Ju M. K., Ahn J., Kim J., Han S-J, Kim T-H, Cechetto J., Nam J., Liuzzi M., Sommer P., No Z. A novel 3,4 dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability. Bioorg. Med. Chem. Lett., 2012, 22(7), 2522-2526. DOI:https://doi.org/10.1016/j.bmcl.2012.01.133
11. Mostafa A. S., Selim K. B. Synthesis and anticancer activity of new dihydropyrimidinone derivatives. Eur. J. Med. Chem., 2018, 156, 304-315. DOI:https://doi.org/10.1016/j.ejmech.2018.07.004
12. Elso O., Liñares G. G., Sülsen V. Current Status on 1, 4-Dihydropyridine Derivatives against Human Pathogenic Parasites. Curr. Top. Med. Chem., 2023, 30(15), 1689-1711. DOI:https://doi.org/10.2174/0929867330666221104162901 EDN: https://elibrary.ru/YHGKGM
13. Panda K. C., Kumar B. R., Sruti J. Microwave assisted synthesis, antihypertensive activity, docking and SAR studies of some dihydropyrimidines. Bioscene, 2024, 21, 1084-1105.
14. Zohny Y. M., Awad S. M., Rabie M. A., Al-Saidan O. A. Synthesis of dihydropyrimidines: isosteres of Nifedipine and evaluation of their calcium channel blocking efficiency. Molecules, 2023, 28(2), 784. DOI:https://doi.org/10.3390/molecules28020784 EDN: https://elibrary.ru/HSNNJJ
15. Kappe C. O. Multicomponent reactions. Weinheim: Wiley‐VCH, 2005, 95-120 pp. DOI: https://doi.org/10.1002/3527605118.ch4
16. Shutalev A. D., Aksenov A. N. Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds. Mendeleev Commun., 2005, 15(2), 73-75. DOI:https://doi.org/10.1070/MC2005v015n02ABEH002023 EDN: https://elibrary.ru/LIWOIB
17. Zhang L., Zhang Z., Liu Q., Liu T., Zhang G. Iron-catalyzed vinylogous aldol condensation of Biginelli products and its application toward pyrido[4,3-d]pyrimidinones. J. Org. Chem., 2014, 79(5), 2281-2288. DOI:https://doi.org/10.1021/jo402773r EDN: https://elibrary.ru/SPBRZN
18. Correa A., Mancheño O. G., Bolm C. Iron-catalysed carbon–heteroatom and heteroatom–heteroatom bond forming processes. Chem. Soc. Rev., 2008, 37(6), 1108-1117. DOI:https://doi.org/10.1039/B801794H EDN: https://elibrary.ru/MMNMHX
19. Sherry B. D., Fürstner A. The promise and challenge of iron-catalyzed cross coupling. Acc. Chem. Res., 2008, 41(11), 1500-1511. DOI:https://doi.org/10.1021/ar800039x
20. Hu E. H., Sidler D. R., Dolling U. H. Unprecedented catalytic three component one-pot condensation reaction: an efficient synthesis of 5-alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones. J. Org. Chem., 1998, 63(10), 3454-3457. DOI:https://doi.org/10.1021/jo970846u
