from 01.01.2022 to 01.01.2024
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Proveden sintez liganda – spirokarbona (4,4,10,10-tetrametil-1,3,7,9-tetraazospiro[5.5]undekan-2,8-diona) i koordinacionnyh soedineniy spirokarbona s kationami perehodnyh metallov: Co2+, Cd2+, La3+, Cu2+, Zn2+, Mn2+. Obrazovanie koordinacionnyh soedineniy podtverzhdeno dannymi IK i UF-spektroskopii. V elektronnyh spektrah kompleksnyh soedineniy zafiksirovan batohromnyy sdvig polosy, sootvetstvuyuschey ligandu, a takzhe poyavlenie novyh maksimumov pogloscheniya v dlinnovolnovoy oblasti. Na osnovanii rezul'tatov molekulyarnogo dokinga bylo pokazano, chto naydennaya biologicheskaya mishen' – α-sinuklein, svyazyvaetsya s ligandom (spirokarbonom) posredstvom vodorodnyh svyazey mezhdu atomami kisloroda i vodoroda amidnoy gruppy 4,4,10,10-tetrametil-1,3,7,9-tetraazospiro[5.5]undekan-2,8-diona i atomami vodoroda i kisloroda aminokislotnyh ostatkov belka. Issledovana zavisimost' lipofil'nosti ot rN sredy kompleksnyh soedineniy spirokarbona
spirokarbon, IK spektroskopiya, elektronnaya spektroskopiya, perehodnye metally, kompleksoobrazovanie, PASS online, molekulyarnyy doking.
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