с 01.01.2022 по 01.01.2024
Ярославль, Ярославская область, Россия
Ярославль, Ярославская область, Россия
Ярославль, Ярославская область, Россия
The synthesis of the ligand – spirocarbon (4,4,10,10-tetramethyl-1,3,7,9-tetraazaspiro[5.5]undecane-2,8-dione) – and its coordination compounds with transition metal cations (Co2+, Cd2+, La3+, Cu2+, Zn2+, Mn2+) has been conducted. The formation of the coordination compounds was confirmed by IR and UV spectroscopy. The electronic spectra of the complexes recorded a bathochromic shift of the band corresponding to the ligand along and the appearance of new absorption maxima in the long-wavelength region. According to molecular docking results, the identified biological target - α-synuclein - binds to the ligand (spirocarbon) via hydrogen bonds between the oxygen and hydrogen atoms of the amide group of 4,4,10,10-tetramethyl-1,3,7,9-tetraazaspiro[5.5]undecane-2,8-dione and the hydrogen and oxygen atoms of the amino acid residues of the protein. The dependence of the spirocarbon complexes lipophilicity on the pH of the medium was investigated.
spirocarbon, IR spectroscopy, electronic spectroscopy, transition metals, complexation, PASS online, molecular docking
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