Ярославль, Ярославская область, Россия
Ярославль, Ярославская область, Россия
Ярославль, Ярославская область, Россия
Ярославль, Ярославская область, Россия
Ярославль, Ярославская область, Россия
УДК 661.162.2 Средства для уничтожения сорной растительности. Гербициды
The authors first synthesised sulfonylurea derivatives incorporating 6 methyluracil and 1,3,4-thiadiazole fragments with 79-81 % yield. The authors conducted field tests of the obtained compounds to determine their herbicidal activity. As a result, the synthesised compounds exhibit a herbicidal activity (53%) close to that of Rubit (61%) and higher than that of Magnum herbicide (41%).
CPCPs, sulfonylureas, herbicides, cropCSM, biological testing
1. Dorozhkina L.A., Poddymkina L.M. Application of herbicides and growth regulators in plant protection: textbook. Moscow: MESKH, 2021, 206 p. (in Russian).
2. Kulikova N.A., Lebedeva G.F. Herbicides and ecological aspects of their use: textbook. Moscow: LIBROCOM Book House, 2010, 152 p. (in Russian).
3. Xie W., Peng C., Chen A., Wang H., Tholley M. S., Qian R., Lu S., Zhang W., Zhan, X. Synergistic adsorption and degradation of sulfonylurea herbicides by biochar-supported nano zero-valent iron composites in in-situ soil remediation. Chem. Eng. J., 2024, 500, 156927. DOI:https://doi.org/10.1016/j.cej.2024.156927.
4. Wei W., Zhou S., Cheng D., Li Y., Liu J., Xie Y., Li Y., Li Z. Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors. Bioorg Med Chem Lett., 2017, 27(15), 3365-3369. DOI:https://doi.org/10.1016/j.bmcl.2017.06.007.
5. Xu Q., Gao Y., Sun Z., Shi J.R., Tang J.Y., Wang Y., Liu Y., Sun X.-W., Li H.-R., Lonhienne Th.G., Niu C.-W., Li Y.-H., Guddat L.W., Wang J.-G. Chemical Synthesis, Herbicidal Activity, Crop Safety, and Molecular Basis of ortho-Fluoroalkoxy Substituted Sulfonylureas as Novel Acetohydroxyacid Synthase Inhibitors. J. Agric. Food Chem. 2024, 72(41), 22595–22605. DOI:https://doi.org/10.1021/acs.jafc.4c05201.
6. Tian T., Song D., Zhang L., Huang H., Li, Y. Facile and selective recognition of sulfonylurea pesticides based on the multienzyme-like activities enhancement of nanozymes combining sensor array. J. Hazard. Mater. 2024, 469, 133847. DOI:https://doi.org/10.1016/j.jhazmat.2024.133847.
7. Alov Ye.M., Novikov S.E., Moskvichev Yu.A., Nikiforov A.V., Kryukova G.G., Smirnova T.M., Berenev B.Ya., Nefedova M.A., Pat. USSR № 1806134, 1990.
8. Gerasimova N.P., Mukhomadiyeva Ye.V., Bulatov A.A., Varvarkin S.V., Khapova S.A., Kuz'micheva S.A. Pat. RF № 2836336, 2024.
9. Pires D.E., Stubbs K.A., Mylne J.S., Ascher D.B. cropCSM: designing safe and potent herbicides with graph-based signatures. Briefings in Bioinformatics, 2022, 23(2), 1-9. DOI:https://doi.org/10.1093/bib/bbac042.
10. Melnikov N.N. Pesticides. Chemistry, technology and application: Textbook for chemical specialities of universities. Moscow: Khimiya, 1987, 712 p. (in Russian).
11. Wang H.-L., Li H.-R., Zhang Y.-C., Yang W.T., Yao Z., Wu R.J., Niu C.W., Li Y.H., Wang J.G. Discovery of ortho-Alkoxy Substituted Novel Sulfonylurea Compounds That Display Strong Herbicidal Activity against Monocotyledon Grasses. J Agric Food Chem. 2021, 69(30), 8415-8427. DOI:https://doi.org/10.1021/acs.jafc.1c02081.
12. Zhang D., Hua X., Liu M., Wu C., Wei W., Liu Y., Li Z. Design, synthesis and herbicidal activity of novel sulfonylureas containing triazole and oxadiazole moieties. Chem. Res. Chin. Univ. 2016, 32, 607–614. DOI:https://doi.org/10.1007/s40242-016-6029-2.
13. Hua X., Zhou S., Chen M., Zhang D., Liu M., Liu J., Li Z. Design, synthesis and herbicidal activity of novel sulfonylureas containing tetrahydrophthalimide substructure. Chem. Res. Chin. Univ. 2016, 32, 396–401. DOI:https://doi.org/10.1007/s40242-016-5480-4.
14. Sheshenev A.Ye., Boltukhina Ye.V., Shkol'nikov N.V., Karakotov S.D. Pat. RF № 2754708, 2021.
15. Golubev, A.S., Makhankova T.A. Methodological recommendations for conducting registration tests of herbicides; ed. by Academician of the Russian Academy of Sciences V.I. Dolzhenko. SPb.: FSBSI VIZR, 2020, 80 p. (in Russian).