Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota

Anna Shubina; Tatyana Orlova

UDC 54-386 UDC 546.654 UDC 615.213

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ISSLEDOVANIE I OTSENKA PROTSESSA KOMPLEKSOOBRAZOVANIYA V SISTEME «KHLORID LANTANA(III) – ASKORBINOVAYA KISLOTA Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota

АА Аа

Published in From Chemistry Towards Technology Step-By-Step · Volume 7, Issue 3, 2026 · Pages 102–112 · Rubric: Scientific articles

Received: 02.06.2026 Accepted: 14.07.2026 Published: 23.09.2026

Authors

Anna Shubina

Tatyana Orlova

Anna Shubina

Yaroslavl State University student · Institute of Fundamental and Applied Chemistry · Russian Federation · Yaroslavl

Tatyana Orlova

Academic degree: candidate of chemical sciences

Yaroslavl State University candidate of chemical science, docent · Institute of Fundamental and Applied Chemistry · Russian Federation · Yaroslavl

ABSTRACT

V rabote vypolnen sintez koordinacionnogo soedineniya lantana(III) s L-askorbinovoy kislotoy v myagkih usloviyah (ledyanaya banya, rN 7). Sostav i stroenie kompleksa podtverzhdeny dannymi elementnogo analiza, IK- i UF-vidimoy spektroskopii, ustanovleno sootnoshenie metall : ligand = 1:1. Opredelena konstanta nestoykosti soedineniya spektrofotometricheskim metodom. Virtual'nyy skrining s ispol'zovaniem resursov PASS Online i ProTox vypolnen s cel'yu prognoza biologicheskoy aktivnosti i toksikologicheskih effektov svobodnoy askorbinovoy kisloty i ee kompleksa s lantanom(III). Pokazano, chto kompleksoobrazovanie privodit k transformacii farmakologicheskogo profilya: snizhaetsya antioksidantnaya aktivnost', no poyavlyaetsya vyrazhennoe ingibirovanie NADPH-peroksidazy i ubihinol-citohrom-S-reduktazy, a takzhe osmoticheskoe diureticheskoe deystvie. Toksikologicheskiy profil' kompleksa harakterizuetsya metabolicheskim acidozom, giperglikemiey, nefrotoksichnost'yu pri otsutstvii kardiotoksichnosti, mutagennosti i kancerogennosti, pri etom prognoz v otnoshenii gepatotoksichnosti neodnoznachen i trebuet eksperimental'noy proverki. Sdelan vyvod o perspektivnosti dal'neyshego izucheniya askorbatov redkozemel'nyh elementov kak soedineniy s potencial'noy biologicheskoy aktivnost'yu.

KEYWORDS

Lantan, askorbinovaya kislota, kompleksoobrazovanie, spektrofotometriya, IK-spektroskopiya, virtual'nyy skrining, PASS Online, ProTox, biologicheskaya aktivnost', toksikologicheskiy profil'.

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Editor in chief

Dmitry Berezin

Deputy Editor in Chief

Igor Abramov

abramovig@ystu.ru

Executive secretary

Zhanna Chirkova

chirkovazhv@ystu.ru

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Shubina A. A., Orlova T. N. Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota // From Chemistry Towards Technology Step-By-Step. 2026. no. 3. pp. 102-112. URL: https://chemintech.ru/en/nauka/publications/article/6ab1151ef4b84411e81b06e2/issledovanie-i-otsenka-protsessa-kompleksoobrazovaniya-v-sisteme-khlorid-lantana-iii-askorbinovaya-kislota/view. (Date of access 29.09.2026).

MLA

Anna Shubina, Orlova T. N.. "Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota." From Chemistry Towards Technology Step-By-Step 7.3 (2026): 102-112. URL: https://chemintech.ru/en/nauka/publications/article/6ab1151ef4b84411e81b06e2/issledovanie-i-otsenka-protsessa-kompleksoobrazovaniya-v-sisteme-khlorid-lantana-iii-askorbinovaya-kislota/view.

APA

Shubina A. A., Orlova T. N. (2026). Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota. From Chemistry Towards Technology Step-By-Step, 7(3), 102-112. URL: https://chemintech.ru/en/nauka/publications/article/6ab1151ef4b84411e81b06e2/issledovanie-i-otsenka-protsessa-kompleksoobrazovaniya-v-sisteme-khlorid-lantana-iii-askorbinovaya-kislota/view

Chicago

Anna Shubina, Orlova T. N.. "Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota." From Chemistry Towards Technology Step-By-Step 7, no. 3 (2026): 102-112. URL: https://chemintech.ru/en/nauka/publications/article/6ab1151ef4b84411e81b06e2/issledovanie-i-otsenka-protsessa-kompleksoobrazovaniya-v-sisteme-khlorid-lantana-iii-askorbinovaya-kislota/view.

WIKI

{{cite journal | author = Shubina A. A., Orlova T. N. | title = Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota | journal = From Chemistry Towards Technology Step-By-Step | year = 2026 | volume = 7 | issue = 3 | pages = 102-112 | url = https://chemintech.ru/en/nauka/publications/article/6ab1151ef4b84411e81b06e2/issledovanie-i-otsenka-protsessa-kompleksoobrazovaniya-v-sisteme-khlorid-lantana-iii-askorbinovaya-kislota/view }}

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ISSLEDOVANIE I OTSENKA PROTSESSA KOMPLEKSOOBRAZOVANIYA V SISTEME «KHLORID LANTANA(III) – ASKORBINOVAYA KISLOTA Issledovanie i otsenka protsessa kompleksoobrazovaniya v sisteme «khlorid lantana(III) – askorbinovaya kislota

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