O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami

Elena Vasil'eva; Polina Polunina; Egor Balbuckiy; Irina K. Proskurina; Sergey Ivanovskiy; Anton Shetnev; Mikhail Korsakov

doi:10.52957/2782-1900-2024-5-4-8-15

UDC 547.793

O-ALKILIROVANIE 4-GIDROKSIBENZOLSUL'FONAMIDA N-ZAMESHCHENNYMI 2-HLORACETAMIDAMI I 5 (HLORMETIL)-3-ARIL-1,2,4-OKSADIAZOLAMI O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami

АА Аа

Published in From Chemistry Towards Technology Step-By-Step · Volume 5, Issue 4 · Pages 8–15 · Rubric: Scientific articles

DOI: https://doi.org/10.52957/2782-1900-2024-5-4-8-15

Received: 01.11.2024 Accepted: 19.11.2024 Published: 23.12.2024

Authors

Elena Vasil'eva

Polina Polunina

Egor Balbuckiy

Irina K. Proskurina

et al.

Sergey Ivanovskiy

Anton Shetnev

Mikhail Korsakov

Elena Vasil'eva

Rossiyskiy gosudarstvennyy universitet im. A.N. Kosygina Russian Federation

Polina Polunina

Yaroslavl State Pedagogical University named after K.D. Ushinsky Yaroslavl

Egor Balbuckiy

Yaroslavl State Pedagogical University named after K.D. Ushinsky Yaroslavl

Irina K. Proskurina

Academic degree: candidate of sciences in biology

Yaroslavl State Pedagogical University named after K.D. Ushinsky Associate Professor · Yaroslavl

Sergey Ivanovskiy

Academic degree: candidate of chemical sciences

Yaroslavl State Pedagogical University named after K.D. Ushinsky Associate Professor · Yaroslavl

Anton Shetnev

Academic degree: candidate of chemical sciences

Yaroslavl State Pedagogical University named after K.D. Ushinsky Associate Professor · Yaroslavl

Yaroslavl State Medical University of the Ministry of Health of Russia Russian Federation · Yaroslavl

Mikhail Korsakov

Academic degree: doctor of chemical sciences

Yaroslavl State Pedagogical University named after K.D. Ushinsky Professor · Yaroslavl

ABSTRACT

Razrabotan sposob sinteza novyh predstaviteley klassa pervichnyh benzolsul'fonamidov, perspektivnyh agentov dlya lecheniya otkrytougol'noy glaukomy i neyrodegenerativnyh zabolevaniy. Byla razrabotana metodika O-alkilirovaniya 4 gidroksibenzolsul'fonamida alkiliruyuschimi agentami razlichnoy prirody, obespechivayuschaya myagkie usloviya i selektivnost' processa. Pokazana neobhodimost' aktivacii N-zameschennyh 2-hloracetamidov i 5-(hlormetil)-3-aril-1,2,4-oksadiazolov kataliticheskoy dobavkoy yodida kaliya v reakciyah O-alkilirovaniya fenolov. Primenimost' razrabotannoy metodiki prodemonstrirovana na 12 primerah sinteza O alkilproizvodnyh 4-gidroksibenzolsul'fonamida, poluchennyh s vyhodami ot 28 do 86%. Chistota i stroenie novyh soedineniy dokazany sovokupnost'yu metodov YaMR 1N, 13S i elementnogo analiza.

KEYWORDS

sul'fanilamid, oksadiazol, O-alkilirovanie, karboangidraza, monoaminooksidaza

Funding

Stat'ya podgotovlena v ramkah gosudarstvennogo zadaniya Yaroslavskogo gosudarstvennogo pedagogicheskogo universiteta im. K. D. Ushinskogo na 2024 god ot Minprosvescheniya RF po teme «Razrabotka novogo lekarstvennogo sredstva dlya lecheniya neyrodegenerativnyh zabolevaniy na osnove ingibitora monoaminoksidazy» (nomer reestrovoy zapisi 720000F.99.1.BN62AA12000)

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GOST

Vasil'eva E. A., Polunina P. V., Balbuckiy E. A., Proskurina I. K., Ivanovskiy S. A., Shetnev A. A., Korsakov M. K. O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami // From Chemistry Towards Technology Step-By-Step. 2024. no. 4. pp. 8-15. DOI: https://doi.org/10.52957/2782-1900-2024-5-4-8-15. (Date of access 19.10.2026).

MLA

Elena Vasil'eva, Polunina P. V., Balbuckiy E. A., Proskurina I. K., Ivanovskiy S. A., Shetnev A. A., Korsakov M. K.. "O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami." From Chemistry Towards Technology Step-By-Step 5.4 (2024): 8-15. DOI: https://doi.org/10.52957/2782-1900-2024-5-4-8-15.

APA

Vasil'eva E. A., Polunina P. V., Balbuckiy E. A., Proskurina I. K., Ivanovskiy S. A., Shetnev A. A., Korsakov M. K. (2024). O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami. From Chemistry Towards Technology Step-By-Step, 5(4), 8-15. https://doi.org/10.52957/2782-1900-2024-5-4-8-15

Chicago

Elena Vasil'eva, Polunina P. V., Balbuckiy E. A., Proskurina I. K., Ivanovskiy S. A., Shetnev A. A., Korsakov M. K.. "O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami." From Chemistry Towards Technology Step-By-Step 5, no. 4 (2024): 8-15. https://doi.org/10.52957/2782-1900-2024-5-4-8-15.

WIKI

{{cite journal | author = Vasil'eva E. A., Polunina P. V., Balbuckiy E. A., Proskurina I. K., Ivanovskiy S. A., Shetnev A. A., Korsakov M. K. | title = O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami | journal = From Chemistry Towards Technology Step-By-Step | year = 2024 | volume = 5 | issue = 4 | pages = 8-15 | doi = 10.52957/2782-1900-2024-5-4-8-15 }}

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O-ALKILIROVANIE 4-GIDROKSIBENZOLSUL'FONAMIDA N-ZAMESHCHENNYMI 2-HLORACETAMIDAMI I 5 (HLORMETIL)-3-ARIL-1,2,4-OKSADIAZOLAMI O-alkilirovanie 4-gidroksibenzolsul'fonamida N-zameshchennymi 2-hloracetamidami i 5 (hlormetil)-3-aril-1,2,4-oksadiazolami

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