Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions

Evgeny Ivanov; Elena Lebedeva; Nadezhda Ivanova; Vladimir Baranov; Angelina Kravchenko

doi:10.52957/27821900_2023_01_86

UDC 544.35.038 UDC 544.353.2 UDC 544.582.6 UDC 546.212.027

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EFFECT OF SOLVENT H/D ISOTOPE SUBSTITUTION AND TEMPERATURE ON SOME THERMODYNAMIC PROPERTIES OF TETRAMETHYLENEDIETHYLENTETRAMINE (PHARMACEUTICAL THEOTROPIN) IN AQUEOUS SOLUTIONS Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions

АА Аа

Published in From Chemistry Towards Technology Step-By-Step · Volume 4, Issue 1 · Pages 86–100 · Rubric: Scientific articles

DOI: https://doi.org/10.52957/27821900_2023_01_86

Received: 13.02.2023 Accepted: 21.03.2023 Published: 23.03.2023 Language of publication: ENG

Authors

Evgeny Ivanov

Elena Lebedeva

Nadezhda Ivanova

Vladimir Baranov

et al.

Angelina Kravchenko

Evgeny Ivanov

Academic degree: candidate of chemical sciences

Institute of Solution Chemistry of G.A. Krestov of the Russian Academy of Sciences Senior Researcher · Ivanovo

Elena Lebedeva

Academic degree: candidate of chemical sciences

Institute of Solution Chemistry of G.A. Krestov of the Russian Academy of Sciences Researcher · Ivanovo

Nadezhda Ivanova

Academic degree: candidate of chemical sciences

Science rang: docent

Ivanovo Power Engineering Institute Ivanovo

Vladimir Baranov

Academic degree: candidate of chemical sciences

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences Researcher · Russian Federation · Moscow

Angelina Kravchenko

Academic degree: doctor of chemical sciences

Science rang: professor

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences Leading Researcher · Russian Federation · Moscow

ABSTRACT

The paper considers the measurements of densities the pharmaceutical “teotro-pine” or tetramethylenediethylenetetramine (TMDETA) solutions in heavy water (D2O) with the solute molality from (0.01 to 0.12) mol∙(kg solvent) 1 at T = (278.15, 288.15, 298.15, 308.15, and 318.15) K and ambient pressure (p = 0.1 MPa). The uncertainty in density measured using the Anton Paar DMA 5000 M densimeter (equipped with oscillating U-tube) was 0.03 kg m-3 or lower. We obtain the standard (at infinite dilution) molar volumes and isobaric expansibilities of TMDETA as a solute in D2O, along with the corresponding solvent D2O–H2O isotope effects (IEs). We define the isotope effects using the previously ob-tained data on volumetric properties of the system (H2O + TMDETA). We also find that the insignificant IEs in the standard molar volume of TMDETA increase with increasing temperature. Based on the analysis of contributions to the standard molar volume of TMDETA in terms of the Scaled Particle Theory (SPT) we confirm that a bulkier molecule of this solute interacts with water (especially, in D2O) actively than it does with a molecule of hexamethylenetetramine (HMTA) or pharmaceutical “urotropine” being the related aminal (cage-like) compound. The colloborating discussion of volume- and enthalpy-isotope characteristics of TMDETA (and HMTA) hydration within the scope of SPT led us to the conclusion that the structure matrix of D2O is more efficient for incorporat-ing the bulkier TMDETA molecule into it

KEYWORDS

teotropine, standard volume and expansibility, standard enthalpy of dissolution, ordinary and heavy water, solvent H/D isotope effect

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Ivanov E. V., Lebedeva E. Y., Ivanova N. G., Baranov V. V., Kravchenko A. N. Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions // From Chemistry Towards Technology Step-By-Step. 2024. no. 1. pp. 86-100. DOI: https://doi.org/10.52957/27821900_2023_01_86. (Date of access 24.09.2026).

MLA

Evgeny Ivanov, Lebedeva E. Y., Ivanova N. G., Baranov V. V., Kravchenko A. N.. "Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions." From Chemistry Towards Technology Step-By-Step 4.1 (2024): 86-100. DOI: https://doi.org/10.52957/27821900_2023_01_86.

APA

Ivanov E. V., Lebedeva E. Y., Ivanova N. G., Baranov V. V., Kravchenko A. N. (2024). Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions. From Chemistry Towards Technology Step-By-Step, 4(1), 86-100. https://doi.org/10.52957/27821900_2023_01_86

Chicago

Evgeny Ivanov, Lebedeva E. Y., Ivanova N. G., Baranov V. V., Kravchenko A. N.. "Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions." From Chemistry Towards Technology Step-By-Step 4, no. 1 (2024): 86-100. https://doi.org/10.52957/27821900_2023_01_86.

WIKI

{{cite journal | author = Ivanov E. V., Lebedeva E. Y., Ivanova N. G., Baranov V. V., Kravchenko A. N. | title = Effect of solvent H/D isotope substitution and temperature on some thermodynamic properties of tetramethylenediethylentetramine (pharmaceutical theotropin) in aqueous solutions | journal = From Chemistry Towards Technology Step-By-Step | year = 2024 | volume = 4 | issue = 1 | pages = 86-100 | doi = 10.52957/27821900_2023_01_86 }}

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