Yaroslavl, Yaroslavl, Russian Federation
student
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
V stat'e rassmotren sintez 3,6-diarildigidro-1,2,4,5-tetrazinov vzaimodeystviem aromaticheskih nitrilov s gidrazingidratom v prisutstvii elementnoy sery. V rezul'tate issledovaniya stroeniya sintezirovannyh digidro-1,2,4,5-tetrazinov s pomosch'yu YaMR 1N spektroskopii i kvantovo-himicheskogo modelirovaniya metodom funkcionala plotnosti s bazisnym naborom 6-31G (d,p) ustanovleno, chto 1,4-digidro- i 1,2-digidrotetraziny blizki po znacheniyam obschey energii i nahodyatsya v smesi v ravnovesii dlya bol'shinstva substratov v priblizitel'no ravnyh kolichestvah. Okisleniem poluchennyh digidro-1,2,4,5-tetrazinov nitritom natriya v ledyanoy uksusnoy kislote sintezirovany sootvetstvuyuschie 3,6 diaril-1,2,4,5-tetraziny, struktura kotoryh podtverzhdena metodom YaMR 1N spektroskopii. Dlya vseh sintezirovannyh celevyh soedineniy prognoziruetsya effektivnoe svyazyvanie s receptorami i fermentami.
tetraziny, aromaticheskie nitrily, gidrazingidrat, digidrotetraziny, reakcii okisleniya
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