From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 96370 10.52957/2782-1900-2025-6-1-22-33 Научные статьи Scientific articles Научные статьи Vnutrimolekulyarnoe aminirovanie orto-nitro-tret-anilinov kak odin iz putej sinteza kondensirovannyh proizvodnyh benzimidazola s uzlovym atomom azota Внутримолекулярное аминирование орто-нитро-трет-анилинов как один из путей синтеза конденсированных производных бензимидазола с узловым атомом азота Бегунов Роман Сергеевич Begunov Roman Sergeevich begunov@bio.ac.ru

кандидат химических наук;

candidate of chemical sciences;

 Савина Луиза Ильинична Savina Luisa Ilyinichna luizasavina2000@mail.ru Астафьева Дария Александровна Astafieva Dariya Aleksandrovna cherry23_00@mail.ru Ярославский государственный медицинский университет Yaroslavl State Medical University Ярославский государственный университет им. П.Г. Демидова P.G. Demidov Yaroslavl State University 24 03 2025 24 03 2025 6 1 22 33 11 12 2024 06 02 2025 https://chemintech.ru/en/nauka/article/96370/view

В работе изучены границы применимости реакции внутримолекулярной восстановительной циклизации орто-нитроаренов, содержащих различные предельные азагетероциклы, для синтеза конденсированных производных бензимидазола с узловым атомом азота. Процесс внутримолекулярной гетероциклизации наблюдался при восстановлении 4-(2-нитроарил)-4-морфолина и 1-(2-нитроарил)-4-метилпиперидина, в то время как наличие в субстрате 4-метил-пиперазинового цикла препятствовало образованию конденсированного полиазагетероцикла

В работе изучены границы применимости реакции внутримолекулярной восстановительной циклизации орто-нитроаренов, содержащих различные предельные азагетероциклы, для синтеза конденсированных производных бензимидазола с узловым атомом азота. Процесс внутримолекулярной гетероциклизации наблюдался при восстановлении 4-(2-нитроарил)-4-морфолина и 1-(2-нитроарил)-4-метилпиперидина, в то время как наличие в субстрате 4-метил-пиперазинового цикла препятствовало образованию конденсированного полиазагетероцикла

 восстановительная внутримолекулярная гетероциклизация орто-нитро-трет-анилины конденсированные производные бензимидазола Работа выполнена в рамках Госзадания на осуществление научных исследований и разработок ФГБОУ ВО «Ярославский государственный медицинский университет» на 2025 год от Министерства здравоохранения РФ по теме «Разработка новых лекарственных препаратов для таргетной химиотерапии онкологических заболеваний на основе конденсированных производных бензимидазола с узловым атомом азота».

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