Sound absorption and thermal conductivity parameters were investigated for different variants of structural design of external and internal walls made of CLT-panels. The authors used the COMSOL Multiphysics software package to evaluate the effectiveness of sound-absorbing materials. It allows modelling the process of sound spreading through a multilayer enclosing structure. The authors recommend using CLT-panels with inner layers of heat- and sound-insulating materials. Such panels provide a high level of factory readiness of structures. The authors studied the sound absorption capacity of structures with mineral wool and polymer foam inserts. The paper considers variations in the arrangement of inserts within CLT-panels and describes their performance at different sound frequencies. The authors have determined the heat conductivity indices of the enclosing structures for the conditions of the Kostroma region by the calculation method. The main element of the structures are five- and seven-layer wooden panels. In this case, the heat insulation layer of mineral wool should be at least 100 mm in seven-layer panels with a thickness of 224 mm.