From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 80968 10.52957/2782-1900-2024-5-1-75-84 Научные статьи Scientific articles Научные статьи Synthesis and characteristics of four new copper(II) carboxylate complexes with adamantane fragment Синтез и характеристика четырех новых карбоксилатных комплексов меди(II) с фрагментом адамантана Красникова Наталия Владимировна Krasnikova Natalia Vladimirovna

кандидат химических наук;

candidate of chemical sciences;

 Красников Сергей Владиславович Krasnikov Sergey Vladislavovich

доктор химических наук;

doctor of chemical sciences;

 Большакова Елизавета Александровна Bolshakova Elizaveta Aleksandrovna Королева Полина Геннадьевна Koroleva Polina Gennadievna Наметкина Анна Андреевна Nametkina Anna Andreevna Ясонов Владимир Сергеевич Yasonov Vladimir Sergeevich Ярославский государственный технический университет Yaroslavl State Technical University ОАО НИИ «Ярсинтез», Ярославль, Россия Ярославль Россия OAO NII (Research Institute) "Yarsintez" Yaroslavl Russian Federation ЯЗГЛФ «Р-Фарм» Ярославль Россия R-Pharm Yaroslavl Russian Federation 23 03 2024 23 03 2024 5 1 75 84 02 02 2024 12 03 2024 https://chemintech.ru/en/nauka/article/80968/view

Синтезированы и охарактеризованы элементным анализом и спектроскопическими методами (ИК, УФ-вид) четыре новых комплекса меди(II) c анионами 1-адамантанкарбоновой, 4-(1-адамантил)бензойной кислот и их L-валиновых производных в качестве лигандов. На основе полученных спектральных данных было сделано предположение о биядерном строении данных комплексов с бидентантной координацией карбоксилатных лигандов типа [Cu2+2(RCOO-)4(H2O)2], где RCOO- – карбоксилатные лиганды. Синтезированные комплексы представляют интерес в качестве потенциальных терапевтических агентов с противовоспалительной и противораковой активностью в сочетании с низкой токсичностью.

The paper considers the results of synthesis, elemental analysis, and spectroscopic methods (IR, UV-vis) of four new copper(II) complexes with anions of 1-adamantanecarboxylic acid, 4-(1-adamantyl)benzoic acid and their L-valine derivatives as ligands. Based on the obtained spectral data, the authors assumed the biyaderic structure of these complexes with bidentate coordination of carboxylate ligands of the type [Cu2+2(RCOO-)4(H2O)2], with RCOO-as carboxylate ligands. The synthesised compounds are of interest as low toxic potential therapeutic agents with anti-inflammatory and anti-cancer activity.

 карбоксилатные комплексы меди(II) 1-адамантанкарбоновая кислота 4-(1-адамантил)бензойная кислота биядерные комплексы copper(II) carboxylate complexes 1-adamantane carboxylic acid 4-(1-adamantyl)benzoic acid biuclear complexes

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