From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 6abbe150f4b844b78f7694e2 10.52957/2782-1900-2026-7-3-122-133 Научные статьи Scientific articles Научные статьи Synthesis, antioxidant activity, and spectral characterization of (E)-3-aryl-5-(arylethenyl) - 1,2,4-oxadiazoles Synthesis, antioxidant activity, and spectral characterization of (E)-3-aryl-5-(arylethenyl) - 1,2,4-oxadiazoles Мигалкина Анастасия Владимировна Migalkina Anastasia Vladimirovna Проскурина Ирина Константиновна Proskurina Irina Konstantinovna

кандидат биологических наук;

candidate of sciences in biology;

 Васильева Елена Андреевна Vasilyeva Elena Andreevna Шетнев Антон Андреевич Shetnev Anton Andreevich

кандидат химических наук;

candidate of chemical sciences;

 Тарасенко Марина Владимировна Tarasenko Marina Vladimirovna

кандидат химических наук;

candidate of chemical sciences;

 Комшина Людмила Александровна Komshina Lyudmila Aleksandrovna

кандидат химических наук;

candidate of chemical sciences;

 Чиркова Жанна Вячеславовна Chirkova Zhanna Vyacheslavovna chirkovazhv@ystu.ru

доктор химических наук;

doctor of chemical sciences;

 Ярославский государственный педагогический университет им. К.Д. Ушинского Ярославль Россия Yaroslavl State Pedagogical University named after K.D. Ushinsky Yaroslavl Russian Federation Ярославский государственный педагогический университет им. К.Д. Ушинского Ярославль Yaroslavl State Pedagogical University named after K.D. Ushinsky Yaroslavl Российский государственный университет им. А.Н. Косыгина (Технологии. Дизайн. Искусство) Москва Россия Russian State University named after A.N. Kosygin (Technology. Design. Art) Moscow Russian Federation Ярославский государственный медицинский университет Минздрава России Yaroslavl Россия Yaroslavl State Medical University of the Ministry of Health of Russia Yaroslavl Russian Federation Ярославский государственный педагогический университет им. К.Д. Ушинского Yaroslavl Россия Yaroslavl State Pedagogical University named after K.D. Ushinsky Yaroslavl Russian Federation Ярославский государственный медицинский университет Минздрава России Yaroslavl Россия Yaroslavl State Medical University of the Ministry of Health of Russia Yaroslavl Russian Federation Ярославский государственный технический университет Ярославль Yaroslavl State Technical University Yaroslavl 02 10 2026 02 10 2026 7 3 122 133 28 06 2026 20 08 2026 © 2026 Мигалкина А.В., Проскурина И.К., Васильева Е.А., Шетнев А.А., Тарасенко М.В., Комшина Л.А., Чиркова Ж.В. © 2026 Migalkina A.V., Proskurina I.K., Vasilyeva E.A., Shetnev A.A., Tarasenko M.V., Komshina L.A., Chirkova Z.V. 2026 Мигалкина Анастасия Владимировна, Проскурина Ирина Константиновна, Васильева Елена Андреевна, Шетнев Антон Андреевич, Тарасенко Марина Владимировна, Комшина Людмила Александровна, Чиркова Жанна Вячеславовна Migalkina Anastasia Vladimirovna, Proskurina Irina Konstantinovna, Vasilyeva Elena Andreevna, Shetnev Anton Andreevich, Tarasenko Marina Vladimirovna, Komshina Lyudmila Aleksandrovna, Chirkova Zhanna Vyacheslavovna Эта статья доступна по лицензии Creative Commons Attribution 4.0 International (CC BY 4.0) This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) https://chemintech.ru/en/nauka/publications/6abbe150f4b844b78f7694e2/view

The article discusses the synthesis and characterization of 5‑(alkenyl)‑3‑aryl‑1,2,4‑oxadiazoles. The synthesis scheme includes two steps: preparation of the triphenylphosphonium chloride and its subsequent condensation with aldehydes. The synthesis conditions for the target products were improved by replacing the base. It increases their yields and allows previously synthetically inaccessible compounds obtaining. The ¹H NMR spectra of the products contain doublets characteristic of double‑bond protons with a coupling constant J = 16.1–16.4 Hz, indicating the E‑configuration of the obtained compounds. Fluorescent and antioxidant properties were found for compounds containing electron‑donating substituents.

The article discusses the synthesis and characterization of 5‑(alkenyl)‑3‑aryl‑1,2,4‑oxadiazoles. The synthesis scheme includes two steps: preparation of the triphenylphosphonium chloride and its subsequent condensation with aldehydes. The synthesis conditions for the target products were improved by replacing the base. It increases their yields and allows previously synthetically inaccessible compounds obtaining. The ¹H NMR spectra of the products contain doublets characteristic of double‑bond protons with a coupling constant J = 16.1–16.4 Hz, indicating the E‑configuration of the obtained compounds. Fluorescent and antioxidant properties were found for compounds containing electron‑donating substituents.

 oxadiazole olefin Wittig reaction antioxidant activity oxadiazole olefin Wittig reaction antioxidant activity This research was financially supported by the Russian Science Foundation (Project No. 25-23-20245).

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